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Postuar mė 8-10-2013 nė 02:18 Edit Post Reply With Quote
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ralph lauren sweater Although hypomethylating agents have shown very interesting activity in large phase II and III clinical trials of MDS,3, 4 different venues for combining these drugs with other therapeutic principles in leukemia and MDS are underway. Among these, the use of epigenetic drugs in the context of adoptive Tcell transfer is particularly interesting. It is based on the discovery by Pinto et al.5 of HLA upregulation by the DNA demethylating agent decitabine in myeloid leukemic blasts and the in vivo observation of upregulation by decitabine of cancer testis Ags such as NYESO1 and a number of MAGE genes.6 On the basis of these results, it is rational to render malignant cells more immunogenic toward Tcell killing by pretreatment with low doses of a hypomethylating agent, which is not intended to exert a primarily cytotoxic effect.A favored therapeutic option for patients with AML and MDS relapsing after allogeneic blood SCT is donor lymphocyte infusions (DLIs),7 as first described by Kolb et al.,8 followed by a second transplant when feasible,9, 10 which in older patients is often not the case.

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