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activity in large phase II and III clinical trials of MDS,3, 4 different venues for combining these drugs with other therapeutic principles in
leukemia and MDS are underway. Among these, the use of epigenetic drugs in the context of adoptive Tcell transfer is particularly interesting. It is
based on the discovery by Pinto et al.5 of HLA upregulation by the DNA demethylating agent decitabine in myeloid leukemic blasts and the in vivo
observation of upregulation by decitabine of cancer testis Ags such as NYESO1 and a number of MAGE genes.6 On the basis of these results, it is
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intended to exert a primarily cytotoxic effect.A favored therapeutic option for patients with AML and MDS relapsing after allogeneic blood SCT is
donor lymphocyte infusions (DLIs),7 as first described by Kolb et al.,8 followed by a second transplant when feasible,9, 10 which in older patients is
often not the case.